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Product Details:
Payment & Shipping Terms:
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| Cas No.: | 30123-17-2 | Other Names: | S-1574 |
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| Product NamRopivacainee: | Tianeptine Sodium Salt | Appearance: | White Powder |
| Assay: | 99% Tianeptine Sodium Salt | Grade: | Pharmaceutical Grade |
| Storage: | Cool Dried Storage | Application: | Pharmaceutical Raw Intermediates |
| High Light: | raw materials for pharma industry,intermediates in pharmaceuticals |
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Description:
Tianeptine sodium salt is a salt of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake . Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptine in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation.
COA:
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Description |
White to yellowish powder,very hygroscopic. |
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Solubility |
Freetly soluble In water and methanol and dichloromethane |
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Identification |
(1)By IR, To match with working standard |
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(2)It gives reaction of sodium |
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Related compounds |
Any impurity ≤0.1% | |
| Total impurities ≤0.4% | ||
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Residual Solvents |
Acetidin≤ 0.5% | |
| Dichloromethane≤ 0.06% | ||
| Methanol 0.3% | ||
| Acetone 0.5% | ||
| Acetonitrile≤0.041% | ||
| Ethanol≤0.5% | ||
| N, N-dimethylformamide ≤0.088% | ||
| Water | ≤ 5.0% | |
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Assay |
99.0%-101.0%(On anhydrous basis) | |
Function:
Tianeptine is antidepressant. The animal has: the hippocampus pyramidal cells increased spontaneous activity, and accelerating its function was inhibited after recovery; increase in cortical and hippocampal neurons at sites of 5- serotonin reuptake. Tianeptine without following adverse effects: sleep and alertness; cardiovascular system; cholinergic system ( without anticholinergic symptoms ); drug craving.
Applicaiton:
Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).
Packing:
Contact Person: bruce
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