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CAS 341031-54-7 Pharmaceutical Raw Material 99%Min Small Molecular Sunitinib Malate

CAS 341031-54-7 Pharmaceutical Raw Material 99%Min Small Molecular Sunitinib Malate

CAS 341031-54-7 Pharmaceutical Raw Material 99%Min Small Molecular Sunitinib Malate
CAS 341031-54-7 Pharmaceutical Raw Material 99%Min Small Molecular Sunitinib Malate CAS 341031-54-7 Pharmaceutical Raw Material 99%Min Small Molecular Sunitinib Malate

Large Image :  CAS 341031-54-7 Pharmaceutical Raw Material 99%Min Small Molecular Sunitinib Malate Get Best Price

Product Details:
Place of Origin: China
Brand Name: XRD
Certification: GMP
Model Number: 341031-54-7
Payment & Shipping Terms:
Minimum Order Quantity: negotiable
Price: Inquiry for Negotiable
Packaging Details: 1-2 kg / aluminum foil bag, 25kg/ drum, as required
Delivery Time: 1-2days after payment received
Payment Terms: T/T bank, Western Union, Bitcoin, Etc
Supply Ability: 100KG/ Month
Detailed Product Description
CAS: 341031-54-7 Product Name: Sunitinib Malate
Type: Anti Tumor Drugs Appearance: White To Yellow Powder
Usage: Anti Cancer Alias: SU 011248
Assay: 99% Key Words: Sunitinib Malate
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CAS 341031-54-7 Pharmaceutical Raw Material

CAS 341031-54-7 Pharmaceutical Raw Material 99%Min Small Molecular Sunitinib Malate 099%min Small Molecular Sunitinib Malate (CAS No.: 341031-54-7)

 

Description:

Name: 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-

Superlist Name: Sunitinib

CAS No.: 557795-19-4

Specification: 99%

Formula: C22H27FN4O2

Molecular Weight: 398.47

Density: 1.23 g/cm3

Melting Point: 189-191 °C

Boiling Point: 572.136 °C at 760 mmHg

Flash Point: 299.818 °C

Appearance: white to yellow powder

 

 

 


Application


Sunitinib malate, also called sunitinib, is a novel, oral, multi-targeted , small molecule oxindole tyrosine kinase inhibitor which inhibits multiple receptor tyrosine kinases including c-KIT, FLT3 kinase, colony-stimulating factor 1 receptor and RET kinase. The IC50 of sunitinib is approximately 10-20 ng/ml to NB cell lines, which is within the clinically relevant human trough serum concentration (50-100 ng/ml).
Receptor tyrosine kinases activated a number of different intracellular signaling pathways.
In neuroblastoma (NB) cell lines, SKN-BE (2), NUB-7, SH-SY5Y and LAN-5, sunitinib significantly inhibited cell proliferation after a treatment for 48 hours, in a concentration-dependent manner.
Treatment with 20, 30 or 40 mg/kg of sunitinib made NOD/SCID mice inoculated with xenograft tumor cells show significant reduction (P <0.05) in primary tumor growth (%T/C: 49% for SK-N-BE (2) and 55% for NB12 tumor, T/C: average treated tumor mass/average control tumor mass). Treatment with different doses of sunitinib (20, 30 or 40 mg/kg) for 14 days resulted in a dramatic decrease in the numbers and size of metastatic sites and a significant difference in liver weight in mice injected intravaneously with 106 SK-N-BE(2) cells for 7 days compared with the control group.

 

 

COA 




Item of analysis
Standard Result of analysis
Description White to pale yellow powder Conforms
Melting piont 215.0-227.0ºc 219.0-220.0ºc
Identification A:IR Conresponding to reference spectrum Conresponding to reference spectrum
  B :HPLC Conresponding to reference rt Conresponding to reference rt
Loss on drying ≤0.5% 0.31%
Residual on lgnition ≤0.5% 0.19%
Residual solvent Pyridine ≤4000ppm ND
  DMF ≤3000ppm ND
  Chloroform ≤4000ppm ND
Ordinary impurities Total impurities≤2.0% 0.30%
Assay 98.0%~101.0% 99.7%


 

 

Other Small molecular API:

AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5

 

CAS 341031-54-7 Pharmaceutical Raw Material 99%Min Small Molecular Sunitinib Malate 1

 

 

99%min Small Molecular Sunitinib Malate (CAS No.: 341031-54-7)

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