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|CAS:||135463-81-9||Product Name:||MKC 231|
|Type:||Pharmaceutical Raw Material||Appearance:||White Powder|
|Usage:||For Improve Cognitive||Alias:||Coluracetam|
|Assay:||99.8%||Key Words:||MKC 231|
memory enhancing supplements
Synonyms:COLURACETAM;N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide;1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-;Coluracetam, MKC-231;1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)carbaMoylMethyl]pyrrolidin-2-one;BCI-540;Coluracetam, >=99%;2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethyl-furo[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide
What is Nootropics
Nootropics are supplements, drugs, or functional foods, that enhance cognitive functions such as intelligence, memory, and focus.
Nootropics, colloquially referred to as "smart drugs," have seen an influx of interest over the last several years as people search for ways to maximize their brain's potential.
What is Coluracetam
(1)Coluracetam, as known as MKC-231 has been classed as a nootropic agent. It's known to enhance cognitive effects, based on the ways in which it influences choline uptake. Originally developed to treat Alzheimer's disease, Coluracetam was found to be more effective as a nootropic and is purely marketed as a cognitive enhancer.
(2)It is one of the newer racetam nootropics to reach the market. Since Coluracetam enhances levels of choline in the brain and body, it increases the production of acetylcholine. Without acetylcholine, we wouldn't be able to remember the simplest of facts or move our muscles. It's been reported that Coluracetam not only increases acetylcholine levels but also speeds up its flow.
Benefits and effects
(1)Coluracetam offers many benefits, however, the most exciting is its ability to improve long-term memory within memory-impaired individuals. Humans have tested Coluracetam, but the majority of testing has taken place with animals. When tested on rats using a commonly used maze test, memory improved. The effects continued, improving memory after this supplement had left their system. This shows that Coluracetam may have potentially long-term effects.
(2)As mentioned, when tested within the Phase 2A trails, Coluracetam showed that it was effective in treating both depression and anxiety. Some patients had not experienced any positive effects in the past by taking anti-depressants, yet experienced the benefits associated with Coluracetam. While assessing depression levels, 36 percent of participants experienced significant improvements.
(3)Many other users also expressed the way in which this supplement creates feelings of contentment and deep peace. When used with other racetams, Coluracetam produces nootropic-like effects. Not only is memory improved, but decision making, along with a number of other cognitive effects increase. This has been shown through a number of studies, reporting that Coluracetam enhances the overall speed of cognition and concentration levels.
(4)Coluracetam has also been shown to have stimulant effects. If you suffer from dreariness in the morning, taking this nootropic could help increase energy levels so that you're able to approach the day with improved motivation. This will help you complete tasks, maintaining an edge in the workplace.
Since the study subjects were mainly rats, there isn't any recommended human dosages, but there is a general guideline for conversion.
In rats, the dosage ranged between 1 mg/kg and 10 mg/kg per day. By using allometric scaling, the dose becomes 2.9 mg/kg in humans, so the average dose should not exceed 203.5 mg daily for someone in a typical weight class.
There isn't very much information to indicate toxicity of Coluracetam, although doses given at the above increments showed no negative side effects. If you haven't used a nootropic before, you may develop headache after use, which is a common in first time users. By stacking the Coluracetam with Choline, you'll reduce this risk.
Memory and Learning
Coluracetam is shown to improve cognitive function and memory in rats, and in theory, the same results are expected in human beings. A study conducted by BrainCells Inc, showed a memory improvement in rats who were given substance AF64A (a neuron-specific neurotoxin) for 8 days along with Coluracetam in 3mg doses. These rats were put through the standardized Morris Water Maze to mark their ability to get through it, and even up to 72 hours after the last 8mg dose, they were still able to. Another key finding of this study was that the results were still apparent 3 days after the last dose, even though the serum concentration of Coluracetam was negligible.
Depression and Anxiety
BrainCells Inc, found that a dosage of 240mg (split into three daily doses of 80mg) was useful in treating major depression co-morbid with GAD (generalized anxiety disorder). However, the differences were most pronounced in those who didn't find relief in using standard antidepressants. After one dose, there were no noticeable differences, but after 2 doses at 80mg, 36% had improved scores during a depression assessment test.
Coluracetam has been associated with optic benefits such as enhanced color vision, recognition and vividness. Although there isn't any conclusive evidence to support the mechanisms behind this benefit, experts believe that Coluracetam works in the part of the brain that runs visual processes.
Nootropic Powder 99% Coluracetam 135463-81-9 MKC 231 For Improve Cognitive
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