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| CAS: | 38183-03-8 | Product Name: | 7,8-DIHYDROXYFLAVONE |
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| Type: | Pharmaceutical Intermediate | Appearance: | Yellow Powder |
| Usage: | Lowering Blood Pressure | Alias: | 7,8-dihydroxy-2-phenyl-4-benzopyrone |
| Assay: | 99%min | Key Words: | 7,8-DIHYDROXYFLAVONE |
| High Light: | brain nootropics,bulk nootropics |
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7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-moleculeagonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor(BDNF).7,8-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier.
7,8-Dihydroxyflavone is disubstituted flavone that acts as a small-molecule TrkB agonist. 7,8-Dihydroxyflavone has been shown to reverse memory deficits and BACE1 elevation in a mouse model of Alzheim er's disease. 7,8-Dihydroxyflavone may also provide a therapeutic option in the treatment of other neorological disorders such as Rett syndrome and PTSD.
Specification:
| Product Name: | 7,8-DIHYDROXYFLAVONE |
| Synonyms: | TIMTEC-BB SBB000930;7,8-DIHYDROXYFLAVONE;7,8-Dihydroxyflavone hydrate |
| CAS: | 38183-03-8 |
| MF: | C15H10O4 |
| MW: | 254.24 |
| EINECS: | 253-812-4 |
| Product Categories: | Di-substituted Flavones;Biochemistry;Flavonoids;Inhibitors |
| Mol File: | 38183-03-8.mol |
| mp | 243-246°C |
| storage temp. | Store at +4°C |
| CAS DataBase Reference | 38183-03-8(CAS DataBase Reference) |
| Chemical Properties | Yellow Solid |
| Biological Activity | Tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (K d = 320 nM). Inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo . |
99% 7,8-Dihydroxyflavone Yellow Powder Lowering Blood Pressure CAS 38183-03-8
Contact Person: Linda Yang
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