Pharmaceutical Intermediates Neomycin Sulfate CAS 1405-10-3 For Antibacterial

Pharmaceutical Intermediates Neomycin Sulfate CAS 1405-10-3 For Antibacterial

1 . Quick Details:

2 . Description:

Neomycin sulfate is a kind of aminoglycoside antibiotics. This product to staphylococcus aureus (methicillin sensitive strains), corynebacterium genus, e. coli, klebsiella bacteria genera, proteus and enterobacteriaceae bacteria have good antibacterial effect, for each group streptococcus, streptococcus pneumoniae, enterococcus is active. This article pseudomonas aeruginosa, oxygen resistance.Bacteria to streptomycin, kanamycin and neomycin, have a partial or total cross resistance between gentamycin.

Neomycin sulphate is a kind of aminoglycoside antibiotics.This product to staphylococcus aureus (methicillin sensitive strains), corynebacterium genus, e. coli, klebsiella bacteria genera, proteus and enterobacteriaceae bacteria have good antibacterial effect, for each group streptococcus, streptococcus pneumoniae, enterococcus is active.This article pseudomonas aeruginosa, oxygen resistance.Bacteria to streptomycin, kanamycin and neomycin, have a partial or total cross resistance between gentamycin.Neomycin systemic medication has significant nephrotoxicity and ototoxicity, is currently limited to oral or topical application.

3 . Usage:

Characteristic of this product is white or kind of white powder;Odourless;Easy to lead wet;Aqueous solution show dextral light.The product easy to dissolve in water, in ethanol, ether, acetone, or almost insoluble in chloroform.Identify

(1) take this product for about 10 mg, add water 1 ml dissolves, add 2 ml of hydrochloric acid solution (9-100), heated in water bath for 10 minutes, with 2 ml of 8% sodium hydroxide solution and 2% acetyl acetone solution 1 ml, water bath heating in 5 minutes. After cooling, add to dimethyl amino benzene formaldehyde test solution 1 ml, namely the cherry red.

(2) apply the product standard and neomycin, respectively made each 1 ml contains 20 mg of water solution.According to thin layer chromatography (TLC) test, 1 mu l learned these two solution, each point in the same silica gel H thin layer plate (silica gel h1.5o g 6 ml with 0.25% sodium carboxymethyl cellulose solution mixing plate), acetic acid with methanol - - acetone - 8.8% ammonium acetate solution (corresponding: 10:40:) as developing agent, unfolds, dry, dry in 110 ºC for 20 minutes, by hot spraying with 10% sodium hypochlorite solution, the thin layer plate on ventilation, cooling, a spray starch potassium iodide solution (0.5% starch solution contained 0.5 g of potassium iodide in the 100 ml), immediately.Show the main spots by color of test sample solution and location should be the same as the main mark of the standard solution.

(3) of this article show the identification of sulphate aqueous reaction.

4 . Function:

Oral administration can be used to:

(1). Neomycin Sulfate can used to Intestinal infection.
(2). Neomycin Sulfate Can also be used as an adjuvant therapy for bowel preparation before colon surgery or hepatic coma.Neomycin should not be used for the treatment of systemic infections.Mainly for the treatment of trachoma, conjunctivitis, and so on.

5 . COA:

 
Veterinary Drugs List
 

Pharmaceutical Intermediates Neomycin Sulfate CAS 1405-10-3 For Antibacterial